Kearns-Sayre syndrome (KSS) is a rare mitochondrial myopathy that usually develops before 20 years of age.It demonstrates multisystemic involvement with a triad of cardinal features: Diabetic Socks progressive ophthalmoplegia, pigmentary retinopathy, and cardiac conduction abnormalities.In addition, patients might have cerebellar ataxia, a high con
The surrounding rock of the roadway under double gobs in the lower coal seams is partially damaged by the mining of the upper coal seam and the stress superimposition of the stepped coal pillars.What is worse, the upper layer of the roof is collapse gangue in double gobs, which makes the anchor cable unable to anchor the reliable bearing layer, so
Background: A mechanism of innate antiviral immunity operating against viruses infecting mammalian cells has been described during the last decade.Host cytidine deaminases (e.g., APOBEC3 proteins) edit viral genomes, giving rise to hypermutated nonfunctional viruses; consequently, Basket viral fitness is reduced through lethal mutagenesis.By contra
Rosemary (Rosmarinus officinalis L.) represents a medicinal plant known for its various health-promoting properties.Its extracts and essential oils exhibit antioxidative, anti-inflammatory, anticarcinogenic, and antimicrobial activities.The main compounds responsible for these effects are the diterpenes carnosic acid, carnosol, and rosmanol, as wel
Neuromedin-U (NMU) is an evolutionarily conserved peptide that regulates varying physiologic effects including blood pressure, stress and allergic responses, metabolic and feeding behavior, pain perception, and neuroendocrine functions.Recently, several lines of investigation implicate NMU in regulating bone remodeling.For instance, global loss of